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Proceedings Paper

Connectivity analysis of anterior nuclei of the thalamus in diffusion-MRI using constrained spherical deconvolution (CSD), multi-shell multi-tissue CSD and probabilistic DTI for ANT-DBS in epilepsy
Author(s): Ruhunur Özdemir; Kai Lehtimäki M.D.; Jukka Peltola M.D.; Hannu Eskola
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Paper Abstract

The anterior nuclei of the thalamus (ANT) have been a promising target in order to control and reduce epileptic seizures for deep brain stimulation surgery (DBS). There are several theories on the structural connectivity of ANT, but clear evidence is still missing. The clinical studies show that each subdivision of the ANT presents different patterns of connectivity throughout the hippocampus, mammillary bodies, and neocortex. Diffusion MRI is a well-known technique that non‐invasively investigates the microstructural organization and orientation of biological tissues in vivo. Diffusion tensor imaging (DTI) is one of the models that has been widely accepted in order to examine the human brain, although it does not accurately reveal the fiber orientations of complex structures due to the presence of crossing fibers. Constrained spherical deconvolution (CSD) can be used to reveal the fiber orientations, overcoming the limitations of DTI. Recent studies show that the b value and gradient directions also play a significant role in extracting fiber orientations in such complex structures. These methods enable a more accurate tractography and investigation of the structural connectivity. In this paper, we demonstrate an approach for the connectivity analysis of ANT by determining different ROIs in the Papez circuit.

Paper Details

Date Published: 28 February 2020
PDF: 8 pages
Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1131721 (28 February 2020); doi: 10.1117/12.2549373
Show Author Affiliations
Ruhunur Özdemir, Tampere Univ. (Finland)
Kai Lehtimäki M.D., Tampere Univ. Hospital (Finland)
Jukka Peltola M.D., Tampere Univ. Hospital (Finland)
Hannu Eskola, Tampere Univ. (Finland)
Tampere Univ. Hospital (Finland)


Published in SPIE Proceedings Vol. 11317:
Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging
Andrzej Krol; Barjor S. Gimi, Editor(s)

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