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Proceedings Paper

Polypyrrole nanoparticles as drug delivery and photothermal agents (Conference Presentation)
Author(s): Connor L. West; Austin C. V. Doughty; Kaili Liu; Wei R. Chen

Paper Abstract

Laser Immunotherapy (LIT) is a novel treatment for metastatic cancer that uses laser irradiation and an immunostimulant to achieve lasting anti-tumor immunity. To increase photothermal conversion efficiency, LIT has used several types of agents tuned to absorb near-infrared (NIR) light. Polypyrrole (PPy) is an organic polymer with similar light absorbing characteristics to previously studied nanomaterials. We carried out dose-dependent PPy toxicity, stability, and photothermal experiments using a mouse breast cancer model. The marked stability under laser irradiation, coupled with PPy’s high photothermal conversion efficiency and low toxicity suggest that PPy could replace nanomaterials as a photothermal and drug-delivery agent.

Paper Details

Date Published: 6 March 2020
Proc. SPIE 11241, Biophotonics and Immune Responses XV, 1124109 (6 March 2020); doi: 10.1117/12.2549338
Show Author Affiliations
Connor L. West, Univ. of Central Oklahoma (United States)
Austin C. V. Doughty, Univ. of Central Oklahoma (United States)
Kaili Liu, Univ. of Central Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 11241:
Biophotonics and Immune Responses XV
Wei R. Chen, Editor(s)

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