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Proceedings Paper

High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)
Author(s): Trevor Mitcham; Dmitry Nevozhay; Aaron Schwartz-Duval; Stephen Lai; Konstantin Sokolov; Richard Bouchard

Paper Abstract

Current molecular imaging modalities face barriers to clinical implementation, providing a need for an improved clinical molecular imaging approach. We hypothesize that EGFR-targeted perfluorocarbon nanodroplets can label metastatic cells; they can then be activated (i.e., converted to a microbubble) and imaged using ultrasound in order to provide a molecular contrast agent that can inform treatment. Pulse sequences were developed for the Verasonics Vantage 128 system to activate and image dodecafluoropentane and dodecafluorohexane nanodroplets. Dodecafluoropentane nanodroplets provided 28-dB enhancement when imaged with pulse-inversion US in a tissue-mimicking environment, while dodecafluorohexane nanodroplets showed activation and subsequent recondensation, allowing for super-resolution imaging.

Paper Details

Date Published: 27 March 2020
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Proc. SPIE 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography, 113190Q (27 March 2020); doi: 10.1117/12.2549324
Show Author Affiliations
Trevor Mitcham, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Dmitry Nevozhay, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Aaron Schwartz-Duval, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Stephen Lai, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Konstantin Sokolov, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Richard Bouchard, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 11319:
Medical Imaging 2020: Ultrasonic Imaging and Tomography
Brett C. Byram; Nicole V. Ruiter, Editor(s)

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