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Proceedings Paper

Robust radiomic feature selection in digital mammography: understanding the effect of imaging acquisition physics using phantom and clinical data analysis
Author(s): Raymond J. Acciavatti; Eric A. Cohen; Omid Haji Maghsoudi; Aimilia Gastounioti; Lauren Pantalone; Meng-Kang Hsieh; Emily F. Conant; Christopher G. Scott; Stacey J. Winham; Karla Kerlikowske; Celine Vachon; Andrew D. A. Maidment; Despina Kontos
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Paper Abstract

Studies have shown that combining calculations of radiomic features with estimates of mammographic density results in an even better assessment of breast cancer risk than density alone. However, to ensure that risk assessment calculations are consistent across different imaging acquisition settings, it is important to identify features that are not overly sensitive to changes in these settings. In this study, digital mammography (DM) images of an anthropomorphic phantom (“Rachel”, Gammex 169, Madison, WI) were acquired at various technique settings. We varied kV and mAs, which control contrast and noise, respectively. DM images in women with negative screening exams were also analyzed. Radiomic features were calculated in the raw (“FOR PROCESSING”) DM images; i.e., grey-level histogram, co-occurrence, run length, fractal dimension, Gabor Wavelet, local binary pattern, Laws, and co-occurrence Laws features. For each feature, the range of variation across technique settings in phantom images was calculated. This range was scaled against the range of variation in the clinical distribution (specifically, the range corresponding to the middle 90% of the distribution). In order for a radiomic feature to be considered robust, this metric of imaging acquisition variation (IAV) should be as small as possible (approaching zero). An IAV threshold of 0.25 was proposed for the purpose of this study. Out of 341 features, 284 features (83%) met the threshold IAV ≤ 0.25. In conclusion, we have developed a method to identify robust radiomic features in DM.

Paper Details

Date Published: 16 March 2020
PDF: 9 pages
Proc. SPIE 11314, Medical Imaging 2020: Computer-Aided Diagnosis, 113140W (16 March 2020); doi: 10.1117/12.2549163
Show Author Affiliations
Raymond J. Acciavatti, Penn Medicine (United States)
Eric A. Cohen, Penn Medicine (United States)
Omid Haji Maghsoudi, Penn Medicine (United States)
Aimilia Gastounioti, Penn Medicine (United States)
Lauren Pantalone, Penn Medicine (United States)
Meng-Kang Hsieh, Penn Medicine (United States)
Emily F. Conant, Penn Medicine (United States)
Christopher G. Scott, Mayo Clinic (United States)
Stacey J. Winham, Mayo Clinic (United States)
Karla Kerlikowske, Univ. of California, San Francisco (United States)
Celine Vachon, Mayo Clinic (United States)
Andrew D. A. Maidment, Penn Medicine (United States)
Despina Kontos, Penn Medicine (United States)


Published in SPIE Proceedings Vol. 11314:
Medical Imaging 2020: Computer-Aided Diagnosis
Horst K. Hahn; Maciej A. Mazurowski, Editor(s)

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