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Proceedings Paper

Heartbeat recovery after cardiac arrest and association of maximum pace-able heart rate with aging via optogenetic pacing and OCM imaging of Drosophila (Conference Presentation)
Author(s): Jing Men; Airong Li; Zhiwen Yang; Jixu Yu; Rudolph Tanzi; Chao Zhou

Paper Abstract

Here, we established NpHR Drosophila model, and demonstrated a heartbeat recovery process after red-light excitation induced cardiac arrest. The maximum heart rate (maxHR) and heart rate recovery time increased with prolonged cardiac arrest. ReaChR fly model was also developed to study the relationship of maximum pace-able heart rate (maxPR) with aging. Older flies showed decreased maxPR. An optical coherence microscopy (OCM) system was used to monitor the heart rate in vivo and in real time. The maxHR, recovery time, and maxPR could become promising indicators of cardiac health for various cardiac studies via Drosophila models in future.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112281X (9 March 2020); doi: 10.1117/12.2549151
Show Author Affiliations
Jing Men, Lehigh Univ. (United States)
Airong Li, Massachusetts General Hospital, Harvard Medical School (United States)
Zhiwen Yang, Beihang Univ. (China)
Jixu Yu, Massachusetts General Hospital, Harvard Medical School (United States)
Rudolph Tanzi, Massachusetts General Hospital, Harvard Medical School (United States)
Chao Zhou, Lehigh Univ. (United States)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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