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Proceedings Paper

Indocyanine green provides absorption and spectral contrast for optical coherence tomography at 840 nm in vivo (Conference Presentation)

Paper Abstract

In recent years, there has been growing interest in the application of exogenous contrast agents to supplement the traditional strengths of optical coherence tomography (OCT). Here we present how indocyanine green (ICG), a common fluorescent contrast agent, can provide absorption and spectral contrast for OCT imaging in the mouse eye in vivo. We further demonstrate high stability of spectral contrast measurements for long term monitoring of contrast agents despite intensity fluctuations. This type of contrast-enhanced OCT may be able to provide similar information to ICG fluorescence angiography, but with the added benefit of depth-resolution and perfectly coregistered OCT intensity data.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112282B (9 March 2020); doi: 10.1117/12.2548999
Show Author Affiliations
Conrad W. Merkle, Medizinische Univ. Wien (Austria)
Marco Augustin, Medizinische Univ. Wien (Austria)
Danielle J. Harper, Medizinische Univ. Wien (Austria)
Bernhard Baumann, Medizinische Univ. Wien (Austria)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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