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Proceedings Paper

Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)
Author(s): Joy Willemse; Reinier Wener; Fabio Feroldi; Margherita Vaselli; Maximilian G. O. Graefe; Johannes F. de Boer

Paper Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) has been used to extract polarization properties of four different diseased lungs ex vivo, including fibrotic sarcoidosis (FS), chronic obstructive pulmonary disease (COPD), fibrotic extrinsic allergic alveolitis (fibrotic EAA) and cystic fibrosis (CF). An increase in alveoli size has been observed in COPD lungs. Furthermore, an increase in birefringence signal was observed for FS and fibrotic EAA. In CF, a few areas with thick patches of birefringence occurred. The results show potential of in vivo assessment of lung fibrosis. Histology slides of all lungs were acquired, and will be used to further interpret the results.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122811 (9 March 2020); doi: 10.1117/12.2548916
Show Author Affiliations
Joy Willemse, Vrije Univ. Amsterdam (Netherlands)
Reinier Wener, The Netherlands Cancer Institute (Netherlands)
Fabio Feroldi, Vrije Univ. Amsterdam (Netherlands)
Margherita Vaselli, Vrije Univ. Amsterdam (Netherlands)
Maximilian G. O. Graefe, Vrije Univ. Amsterdam (Netherlands)
Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)

Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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