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Proceedings Paper

Gold nanobipyramds as optical coherence tomography contrast agents in the second near infrared window for multiplexing study of tumor lymphatic flows (Conference Presentation)
Author(s): Peng Si; Saba Shevidi; Edwin Yuan; Ke Yuan; Ziv Lautman; Stefanie S. Jeffrey; George W. Sledge; Adam de la Zerda

Paper Abstract

Developing suitable contrast agents is essential for multiplexed optical coherence tomography (OCT), which allows simultaneous imaging of different biomarkers, cells and flows in living subjects. However, few OCT contrast agents have shown multiplexing capability, especially in the second near infrared (NIR-II) window. Here we demonstrate that using gold nanobipyramds as OCT contrast agents, two separate lymph flows can be visualized simultaneously in a live mouse in the NIR-II window. We concurrently traced lymph flows draining from a melanoma tumor and peritumoral tissue upstream of the melanoma, showing these flows exhibit distinct drainage patterns and merge into the same lymph node.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122829 (9 March 2020); doi: 10.1117/12.2548906
Show Author Affiliations
Peng Si, Stanford Univ. School of Medicine (United States)
Saba Shevidi, Stanford Univ. School of Medicine (United States)
Edwin Yuan, Stanford Univ. School of Medicine (United States)
Ke Yuan, Stanford Univ. School of Medicine (United States)
Ziv Lautman, Stanford Univ. School of Medicine (United States)
Stefanie S. Jeffrey, Stanford Univ. School of Medicine (United States)
George W. Sledge, Stanford Univ. School of Medicine (United States)
Adam de la Zerda, Stanford Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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