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Proceedings Paper

Microglia distribution and motility in human eyes measured with adaptive optics – optical coherence tomography (AO-OCT) (Conference Presentation)

Paper Abstract

Microglia are central nervous system macrophages and the first responders to neural injury. Herein we characterize their distribution and motility in human eyes using a multimodal AO system. In healthy eyes, microglia are absent in the central macula up to ~5º eccentricity but their density increases monotonically at higher eccentricities. Microglia density decreases linearly with age. ILM microglia are relatively immobile for durations up to two weeks but their processes re-orient over timescales as short as minutes. The density, motility, and reactive state of microglia may serve as an ocular disease biomarker for early detection and progression monitoring.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121818 (9 March 2020); doi: 10.1117/12.2548639
Show Author Affiliations
Daniel X. Hammer, U.S. Food and Drug Administration (United States)
Ricardo Villanueva, Univ. of Maryland School of Medicine (United States)
Anant Agrawal, U.S. Food and Drug Administration (United States)
Osamah Saeedi, Univ. of Maryland School of Medicine (United States)
Zhuolin Liu, U.S. Food and Drug Administration (United States)


Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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