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Proceedings Paper

In-vivo, non-contact, cellular resolution imaging of the human limbus with line-field SD-OCT at 2.5 kHz frame rate (Conference Presentation)
Author(s): Le Han; Zohreh Hosseinaee; Lin Kun Chen; Kostadinka Bizheva

Paper Abstract

Currently, clinical in-vivo imaging of the human limbus cellular structure is only possible with in-vivo confocal microscopy (IVCM). However, IVCM requires physical contact with the imaged object, and may cause incidental tearing or inflammation of the limbal tissue. We present a line-field, spectral-domain OCT system (LF-SD-OCT) that can generate volumetric, cellular resolution images of biological tissue in-vivo and without contact. The system provides 1.7 µm axial and 2.2 × 3.1 µm lateral resolution in tissue and 2.5 kHz frame rate. The quality of healthy human limbus images acquired with LF-SD-OCT is comparable to that of IVCM.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180O (9 March 2020); doi: 10.1117/12.2548638
Show Author Affiliations
Le Han, Univ. of Waterloo (Canada)
Zohreh Hosseinaee, Univ. of Waterloo (Canada)
Lin Kun Chen, Univ. of Waterloo (Canada)
Kostadinka Bizheva, Univ. of Waterloo (Canada)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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