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Proceedings Paper

Classification of skin-cancer lesions based on fluorescence lifetime imaging
Author(s): Priyanka Vasanthakumari; Renan A. Romano; Ramon G. T. Rosa; Ana G. Salvio; Vladislav Yakovlev; Cristina Kurachi; Javier A. Jo
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Paper Abstract

Every year more than 5.4 million new cases of skin cancer are reported in the US. Melanoma is the most lethal type with only 5% occurrence rate, but accounts for over 75% of all skin cancer deaths. Non-melanoma skin cancer, especially basal cell carcinoma (BCC) is the most commonly occurring and often curable type that affects more than 3 million people and causes about 2000 deaths in the US annually. The current diagnosis involves visual inspection, followed by biopsy of the lesions. The major drawbacks of this practice include difficulty in border detection causing incomplete treatment and, the inability to distinguish between clinically similar lesions. Melanoma is often mistaken for the benign lesion pigmented seborrheic keratosis (pSK), making it extremely important to differentiate benign and malignant lesions. In this work, a novel feature extraction algorithm based on phasors was performed on the Fluorescence Lifetime Imaging (FLIM) images of the skin to reliably distinguish between benign and malignant lesions. This approach, unlike the standard FLIM data processing method that requires time-deconvolution of the instrument response from the measured time-resolved fluorescence signal, is computationally much simpler and provides a unique set of features for classification. Subsequently, FLIM derived features were selected using a double step cross validation approach that assesses the reliability and the performance of the resultant trained classifier. Promising FLIM-based classification performance was attained for detecting benign from malignant pigmented (sensitivity: ~80%, specificity: 79%, overall accuracy: ~79%) and nonpigmented (sensitivity: ~88%, specificity: 83%, overall accuracy: ~87%) lesions.

Paper Details

Date Published: 28 February 2020
PDF: 9 pages
Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 113170Z (28 February 2020); doi: 10.1117/12.2548625
Show Author Affiliations
Priyanka Vasanthakumari, Texas A&M Univ. (United States)
Renan A. Romano, Univ. of São Paulo (Brazil)
Ramon G. T. Rosa, Univ. of São Paulo (Brazil)
Ana G. Salvio, Hospital Amaral Carvalho (Brazil)
Vladislav Yakovlev, Texas A&M Univ. (United States)
Cristina Kurachi, Univ. of São Paulo (Brazil)
Javier A. Jo, The Univ. of Oklahoma (United States)

Published in SPIE Proceedings Vol. 11317:
Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging
Andrzej Krol; Barjor S. Gimi, Editor(s)

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