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Proceedings Paper

Systematic comparison of deep learning strategies for weakly supervised Gleason grading
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Paper Abstract

Prostate cancer (PCa) is one of the most frequent cancers in men. Its grading is required before initiating its treatment. The Gleason Score (GS) aims at describing and measuring the regularity in gland patterns observed by a pathologist on the microscopic or digital images of prostate biopsies and prostatectomies. Deep Learning based (DL) models are the state-of-the-art computer vision techniques for Gleason grading, learning high-level features with high classification power. However, for obtaining robust models with clinical-grade performance, a large number of local annotations are needed. Previous research showed that it is feasible to detect low and high-grade PCa from digitized tissue slides relying only on the less expensive report{level (weakly) supervised labels, thus global rather than local labels. Despite this, few articles focus on classifying the finer-grained GS classes with weakly supervised models. The objective of this paper is to compare weakly supervised strategies for classification of the five classes of the GS from the whole slide image, using the global diagnostic label from the pathology reports as the only source of supervision. We compare different models trained on handcrafted features, shallow and deep learning representations. The training and evaluation are done on the publicly available TCGA-PRAD dataset, comprising of 341 whole slide images of radical prostatectomies, where small patches are extracted within tissue areas and assigned the global report label as ground truth. Our results show that DL networks and class-wise data augmentation outperform other strategies and their combinations, reaching a kappa score of κ = 0:44, which could be further improved with a larger dataset or combining both strong and weakly supervised models.

Paper Details

Date Published: 16 March 2020
PDF: 8 pages
Proc. SPIE 11320, Medical Imaging 2020: Digital Pathology, 113200L (16 March 2020); doi: 10.1117/12.2548571
Show Author Affiliations
Sebastian Otálora, Univ. of Applied Sciences Western Switzerland (Switzerland)
Univ. of Geneva (Switzerland)
Manfredo Atzori, Univ. of Geneva (Switzerland)
Amjad Khan, Univ. of Geneva (Switzerland)
Oscar Jimenez-del-Toro, Univ. of Applied Sciences Western Switzerland (Switzerland)
Vincent Andrearczyk, Univ. of Geneva (Switzerland)
Henning Müller, Univ. of Applied Sciences Western Switzerland (Switzerland)
Univ. of Geneva (Switzerland)

Published in SPIE Proceedings Vol. 11320:
Medical Imaging 2020: Digital Pathology
John E. Tomaszewski; Aaron D. Ward, Editor(s)

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