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Proceedings Paper

Quantification of ex vivo tissue activity by short and long time-course analysis of multifunctional OCT signals
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Paper Abstract

We present a new OCT-based tissue dynamics/subcellular motion analysis method to visualize tissue dynamics, where we increase the functionality of OCT to be sensitive for tissue dynamics by utilizing rapid-time-sequence analysis of OCT signals. These analysis includes log intensity variance (LIV) and OCT time-correlation analysis (OCT decorrelation speed; OCDS). In addition to LIV and OCDS methods, attenuation coefficient (AC), birefringence, and degree of polarization uniformity (DOPU) analysis were performed. These methods used to visualize and quantify long-term tissue dynamics degradation of different tissue types such as dissected mouse liver and tumor spheroids. These methods were quantitative, so the time-course tissue dynamics degradation has been not only visualized as an image, but also quantitative analysis of the dynamics degradation were performed.

Paper Details

Date Published: 21 February 2020
PDF: 5 pages
Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112282C (21 February 2020); doi: 10.1117/12.2548541
Show Author Affiliations
I. G. Abd El-Sadek, Univ. of Tsukuba (Japan)
A. Miyazawa, Univ. of Tsukuba (Japan)
L. T. W. Shen, Univ. of Tsukuba (Japan)
S. Fukuda, Univ. of Tsukuba (Japan)
T. Yamashita, Univ. of Tsukuba (Japan)
Y. Oka, Univ. of Tsukuba (Japan)
P. Mukherjee, Univ. of Tsukuba (Japan)
S. Makita, Univ. of Tsukuba (Japan)
S. Matsusaka, Univ. of Tsukuba (Japan)
T. Oshika, Univ. of Tsukuba (Japan)
H. Kano, Univ. of Tsukuba (Japan)
Y. Yasuno, Univ. of Tsukuba (Japan)

Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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