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Proceedings Paper

Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)

Paper Abstract

Recent Alzheimer’s disease (AD) studies have focused on retinal analysis, as the retina is the only part of the central nervous system which can be imaged non-invasively by optical methods. The appearance of the retina of the APP/PS1 mouse model of AD was therefore evaluated by a custom-built multi-contrast optical coherence tomography (OCT) system. By visualizing retinal changes over a range of ages in intensity-, polarization- and motion-based contrast modes simultaneously, observations in the retina were documented and compared to both retinal whole-mounts and conventional histological sections. The data was also correlated to the cortical amyloid beta plaque load.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181C (9 March 2020); doi: 10.1117/12.2548412
Show Author Affiliations
Bernhard Baumann, Medizinische Univ. Wien (Austria)
Danielle J. Harper, Medizinische Univ. Wien (Austria)
Antonia Lichtenegger, Medizinische Univ. Wien (Austria)
Johanna Gesperger, Medizinische Univ. Wien (Austria)
Tanja Himmel, Veterinaermedizinische Univ. Wien (Austria)
Martina Muck, Medizinische Univ. Wien (Austria)
Conrad W. Merkle, Medizinische Univ. Wien (Austria)
Pablo Eugui, Medizinische Univ. Wien (Austria)
Stefan Kummer, Veterinaermedizinische Univ. Wien (Austria)
Adelheid Woehrer, Medizinische Univ. Wien (Austria)
Martin Glösmann, Veterinaermedizinische Univ. Wien (Austria)
Marco Augustin, Medizinische Univ. Wien (Austria)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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