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Proceedings Paper

Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans
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Paper Abstract

We are developing a platform for virtual (in silico) clinical trials in x-ray breast imaging and dosimetry fully based on Monte Carlo simulations and which adopts patient-like digital phantoms. We report the initial steps and first results of this project. Our collaboration was established for producing a “user-friendly” computational platform which reproduces both 2D (full-fields digital mammography) and 3D (digital breast tomosynthesis, CT dedicated to the breast) breast imaging examinations for technique optimization and for developing protocols and computed aided diagnostic applications. Dose optimization strategies and technique performance comparisons will be explored. A dataset of anatomically realistic, 2D and 3D digital breast phantoms have been produced by means of voxel classification and digital compression of clinical breast CT scans acquired at UC Davis. Monte Carlo simulations, based on the Geant4 toolkit, have been developed for insilico FFDM, DBT and BCT examinations.

Paper Details

Date Published: 16 March 2020
PDF: 8 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 1131259 (16 March 2020); doi: 10.1117/12.2548224
Show Author Affiliations
Giovanni Mettivier, Univ. di Napoli Federico II (Italy)
INFN (Italy)
Antonio Sarno, Univ. di Napoli Federico II (Italy)
INFN (Italy)
John M. Boone, Univ. of California Davis Medical Ctr. (United States)
Kristina Bliznakova, Medical Univ. of Varna (Bulgaria)
Francesca di Franco, Univ. di Napoli Federico II (Italy)
INFN (Italy)
Paolo Russo, Univ. di Napoli Federico II (Italy)
INFN (Italy)


Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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