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Proceedings Paper

Visualization of OCT signal pulsatility at variable tissue depth with optical microangiography
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Paper Abstract

Pulsatile signals from the cutaneous blood flow could be informative for evaluating the health condition of an individual. One of the popular optical measuring devices, photoplethysmogram (PPG) is often used to detect the pulse signal from skin. However, the origin of the PPG signal still remains controversial. Benefiting from the non-invasive, label-free, 3D imaging tool, optical coherence tomography (OCT) is able to capture the intrinsic tissue signals at different penetration depth in high spatial and temporal resolution. Periodic pulse signal was observed by taking advantage of the optical microangiography (OMAG) algorithm which is sensitive to the motion of blood flow. The pulsatile pattern from the capillary and arteriole was successfully differentiated and their morphology showed distinct property at different local blood pressure. The pulse signal from the arteriole is more consistent and has similar waveform as the PPG signals. The result indicated that the PPG signal could be deceive by the mixing signal from the capillary bed and arterioles since it measures the total blood volume change in the plexuses. This study may shed some new light on understanding the mechanical property of how blood travel through different types of vasculature networks and elucidate its potential application in disease assessments.

Paper Details

Date Published: 21 February 2020
PDF: 8 pages
Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390C (21 February 2020); doi: 10.1117/12.2547619
Show Author Affiliations
Zhiying Xie, Univ. of Washington (United States)
Qinqin Zhang, Univ. of Washington (United States)
Yuxuan Cheng, Univ. of Washington (United States)
Geng Wang, Univ. of Washington (United States)
Minh Nhan Le, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 11239:
Dynamics and Fluctuations in Biomedical Photonics XVII
Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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