Share Email Print
cover

Proceedings Paper

High-resolution vascular imaging of small animal using the NIR-IIb window emitted from ICG
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Fluorescence molecular imaging is a promising tool for molecular tracking, and thus can visualize the vascular structure of small animal. However, with the strong scattering in biological tissues, traditional fluorescence molecular imaging in the visible spectrum or the first near-infrared spectrum (NIR-I, 700-900 nm) has a limitation for high-resolution vascular imaging. Recently, the novel in vivo fluorescence molecular imaging in the longer second near-infrared window (NIR-IIb, 1500-1700 nm) is successfully developed for small animal imaging. The NIR-IIb window affords high imaging resolution and deep tissue penetration because of the diminished photon scattering effect, which is suitable for vascular imaging. However, the clinical applications of NIR-IIb fluorescence molecular imaging have been severely limited for lack of the clinical fluorophores. Here, we show that the clinically available dye, indocyanine green (ICG), can also emit the NIR-IIb signal, which provides high-resolution vascular imaging of small animal. We construct a novel imaging system for NIR-I and NIR-IIb imaging simultaneously and perform two vascular imaging experiments. The results demonstrate that the NIR-IIb imaging using ICG shows great superiority for high-resolution vascular imaging of small animal compared with NIR-I imaging. It is believed that this study will facilitate the preclinical and clinical applications of NIR-IIb molecular imaging using ICG in the future.

Paper Details

Date Published: 16 March 2020
PDF: 6 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113122F (16 March 2020); doi: 10.1117/12.2547582
Show Author Affiliations
Meishan Cai, Institute of Automation (China)
Univ. of Chinese Academy of Sciences (China)
Zhenhua Hu, Institute of Automation (China)
Jie Tian, Institute of Automation (China)
Univ. of Chinese Academy of Sciences (China)
Xidian Univ. (China)


Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray