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Proceedings Paper

S2 state optical property enhancement of indocyanine green due to optical exposure
Author(s): Anshu Kumari; Amit Goverdhan; Prashant Kharey; Surjendu B. Dutta; Suman Bishnoi; Saumya Jaiswal; Sharad Gupta
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Paper Abstract

Indocyanine green (ICG) is a United States Food and Drug Administration approved near-infrared (NIR) chromophore used in clinics for the last six decades. It has been used for cardiac output, hepatic function measurements, NIR imaging, and anticancer therapy. ICG is known for its NIR optical properties. in addition to the well-known NIR absorption, ICG also shows an absorption band with a peak maximum at ~400 nm. However, insignificant information is available about its optical properties in the visible wavelength range. The absorption peak at ~400 nm could be referred to as the transition of the electrons from the ground (S0) state to second excited (S2) state. After excitation to the S2 state, these electrons could directly relax to S0 state, this transition causes an emission with a maximum at ~557 nm. ICG is an optically unstable molecule, its NIR absorption and emission deteriorate upon optical exposure. However, optical exposure does not seem to affect the higher energy transitions of ICG adversely. Unlike the NIR emission, the fluorescence emission of ICG at ~557 nm increases upon continuous optical exposure. To the best of our knowledge, this is the first report on the S2 state mediated emission enhancement due to the light exposure of ICG in the visible wavelength range. Improvement in the optical properties of the ICG due to optical exposure might open several exciting areas of research where its application could be broadened.

Paper Details

Date Published: 21 February 2020
PDF: 10 pages
Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340Y (21 February 2020); doi: 10.1117/12.2547501
Show Author Affiliations
Anshu Kumari, Indian Institute of Technology Indore (India)
Amit Goverdhan, Indian Institute of Technology Indore (India)
Prashant Kharey, Indian Institute of Technology Indore (India)
Surjendu B. Dutta, Indian Institute of Technology Indore (India)
Suman Bishnoi, Indian Institute of Technology Indore (India)
Saumya Jaiswal, Indian Institute of Technology Indore (India)
Sharad Gupta, Indian Institute of Technology Indore (India)


Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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