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Establishing diffuse speckle contrast signal relationship with blood flow
Author(s): Jialin Liu; Baoteng Xu; Wei Zhou; Xibin Yang; Daxi Xiong
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Paper Abstract

Diffuse speckle contrast analysis (DSCA) measures blood flow in deep tissues by the sensitivity of speckle contrast signals to the displacement of red blood cells (RBCs). Currently, the most common model for describing the displacement of RBCs is a Brownian diffusion-like process. In fact, RBCs undergo shear-induced displacement in blood flow. In this paper, the reduction in speckle contrast due to shear-induced motions is studied by theory and Monte Carlo simulations. We provide the solution for the speckle contrast function in a semi-infinite geometry, and establish the quantitative relationship between speckle contrast and absolute blood flow in a realistic vascular network. Based on this relationship, we can determine the relative contributions of diffusive RBCs motions on the speckle contrast.

Paper Details

Date Published: 18 December 2019
PDF: 5 pages
Proc. SPIE 11337, AOPC 2019: Optical Spectroscopy and Imaging, 113370Y (18 December 2019); doi: 10.1117/12.2547422
Show Author Affiliations
Jialin Liu, Suzhou Institute of Biomedical Engineering and Technology (China)
Baoteng Xu, Suzhou Institute of Biomedical Engineering and Technology (China)
Wei Zhou, Suzhou Institute of Biomedical Engineering and Technology (China)
Xibin Yang, Suzhou Institute of Biomedical Engineering and Technology (China)
Daxi Xiong, Suzhou Institute of Biomedical Engineering and Technology (China)


Published in SPIE Proceedings Vol. 11337:
AOPC 2019: Optical Spectroscopy and Imaging
Jin Yu; Zhe Wang; Vincenzo Palleschi; Mengxia Xie; Yuegang Fu, Editor(s)

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