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Proceedings Paper

Food based contrast agents for photoacoustic imaging
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Paper Abstract

Photoacoustic (PA) imaging is a hybrid imaging technology which combines the best of optical (contrast) and ultrasound (resolution) imaging. PA imaging uses intrinsic contrast agents in the body like blood (hemoglobin), melanin, etc. But the contrast from the intrinsic contrast agents might not be sufficient for different applications. So, external contrast agents are needed for improving the contrast of PA images. Organic dyes, inorganic dyes, and nanomaterials can be used as photoacoustic contrast agents. The major issue with using external contrast agent is that they often need FDA approval to be used for in-vivo studies. Availability of FDA approved contrast agents for PA imaging is very limited. In this work, we present the feasibility of using food and food-based dyes as photoacoustic contrast agents. We use commonly used foods like coffee, tea, chocolate and food colorants as contrast agents. We use alpinion’s E-CUBE dual mode ultrasound and photoacoustic imaging system with mobile Nd:YAG laser pumped by OPO laser to demonstrate the efficiency of the contrast agents. The contrast agents were compared with methylene blue. Out of the many different agents we tested, coffee, chocolate and few other dyes proved as efficient photoacoustic contrast agents. We performed photoacoustic spectroscopy to identify at which wavelength the dye performed best. We also tested the contrast agents for imaging sentinel lymph nodes in rats and the results are very similar to methylene blue. This will enable the transition of photoacoustic imaging to the clinics more easily.

Paper Details

Date Published: 17 February 2020
PDF: 7 pages
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112403K (17 February 2020); doi: 10.1117/12.2547404
Show Author Affiliations
Kathyayini Sivasubramanian, Stanford Univ. School of Medicine (United States)
Jeesu Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Kai Cheng, Stanford Univ. School of Medicine (United States)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Lei Xing, Stanford Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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