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Proceedings Paper

Image-guided fluorescence tomography in tissue phantom models of oral cancer
Author(s): Michael J. Daly; Jacqueline Fleisig; Harley Chan; Marco Ferrari; Catriona Douglas; Brian C. Wilson; David A. Jaffray; Jonathan C. Irish
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Paper Abstract

Current intraoperative methods to assess tumor invasion depth in mucosal oral cancer provide limited real-time information. The advent of targeted fluorescence contrast agents for head and neck cancer is a promising innovation, but surgical imaging systems typically provide only two-dimensional views. Here, we investigate the use of an image-guided fluorescence tomography (igFT) system to estimate the depth of tumor invasion in tissue-simulating oral cancer phantoms. Implementation of non-contact diffuse optical tomography using finite-element software (NIRFAST) is enabled with geometric data from intraoperative cone-beam CT (CBCT) imaging and surgical navigation. The tissue phantoms used gelatin for the background (5% for fat, 10% for muscle) and 2% agar for palpable, tumor-like inclusions. Standard agents were used for absorption (hemoglobin), scattering (Intralipid), fluorescence (indocyanine green), and CT contrast (iohexol). The agar inclusions were formed using 3D printed molds, and positioned at the surface of the gelatin background to mimic mucosal tumor invasion (an “iceberg” model). Simulations and phantom experiments characterize fluorescence tomography performance across a range of tumor invasion depths. To aid surgical visualization, the fluorescence volume is converted to a colored surface indicating tumor depth, and overlaid on the navigated endoscopic video. Clinical studies are necessary to assess in vivo performance and intraoperative workflow.

Paper Details

Date Published: 6 March 2020
PDF: 8 pages
Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220E (6 March 2020); doi: 10.1117/12.2547348
Show Author Affiliations
Michael J. Daly, Univ. Health Network (Canada)
Jacqueline Fleisig, Univ. Health Network (Canada)
Harley Chan, Univ. Health Network (Canada)
Marco Ferrari, Univ. of Toronto (Canada)
Univ. degli Studi di Brescia (Italy)
Catriona Douglas, Univ. delgi Studi di Brescia (Italy)
Brian C. Wilson, Univ. Health Network (Canada)
David A. Jaffray, Univ. Health Network (Canada)
M.D. Anderson Cancer Ctr. (United States)
Jonathan C. Irish, Univ. Health Network (Canada)
Univ. delgi Studi di Brescia (Italy)

Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)

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