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Proceedings Paper

Multifractal analysis of low coherence spectra for oral cancer detection
Author(s): Gyana Ranjan Sahoo; Dipti Bharti; Asima Pradhan
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Paper Abstract

Morphological changes in tissue are highly correlated with progression of cancer. Such structural changes lead to fluctuations of refractive index (RI) inside the tissue, which are random and exhibit self-similar properties. Depth distribution in RI of oral tissue samples were studied through Fourier domain low coherence interferometry. A halogen tungsten lamp was used as the source, and an Ocean Optics spectrometer was used for the collection of interference spectra. The experimental system was calibrated using mica sheets of different thick- nesses, polystyrene microspheres and polydimethylsiloxane (PDMS). Multifractal detrended fluctuation analysis (MFDFA) were employed on interference spectra to study and quantify multifractality in depth-wise distribution of the RI in oral tissue sections. The derived multifractal parameters, namely the generalized Hurst exponent and the width of the multifractal spectrum, showed quite significant differences among tissues having three different grades of cancer. The depth-wise variation of the refractive index showed an increase in multifractality with increasing pathological grades of cancer.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11253, Biomedical Applications of Light Scattering X, 112530Y (21 February 2020); doi: 10.1117/12.2547189
Show Author Affiliations
Gyana Ranjan Sahoo, Indian Institute of Technology Kanpur (India)
Dipti Bharti, Indian Institute of Technology Kanpur (India)
Asima Pradhan, Indian Institute of Technology Kanpur (India)

Published in SPIE Proceedings Vol. 11253:
Biomedical Applications of Light Scattering X
Adam Wax; Vadim Backman, Editor(s)

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