Share Email Print
cover

Proceedings Paper

Towards quantitative photoacoustic tomography for partial view array transducers
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

One of the challenges of quantitative Photoacoustic (PA) imaging is unmixing the optical absorption (μa) of the tissue from system response (C) and Grüneisen parameter (Γ). In this study, we have calculated the absorption coefficient and functional parameters, i.e. total hemoglobin (tHb) and oxygen saturation (sO2) of 5 blood tubes with sO2 values ranging from 24.9% to 97.6% at different depths in intralipid solution. Beer’s law is used to calculate the optical fluence in the target area. Initial values for μa and C×Γ are found by fitting a line to the log of PA beam data. These initial values are iteratively updated using a conjugate gradient method. This process is repeated for all 11 wavelengths. The absorption coefficient spectrum follows the molar extinction coefficient spectrum of deoxy hemoglobin for lower sO2 percentages, and it becomes closer to the spectrum of oxy hemoglobin when the sO2 percentage increases. The calculated absorption coefficients at 11 wavelengths are used to estimate the absolute value of the tHb and sO2 of each blood sample at different depths. The mean error of the estimated tHb values for blood tubes at all depths with respect to the real values are less than 13%. Moreover, the largest sO2 estimation error is 7.5% for the blood sample with sO2 of 24.9%. Our quantitative PA method performed well for the data collected from blood samples. We are investigating this method on our clinical data.

Paper Details

Date Published: 17 February 2020
PDF: 7 pages
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112404G (17 February 2020); doi: 10.1117/12.2547143
Show Author Affiliations
Eghbal Amidi, Washington Univ. in St. Louis (United States)
Guang Yang, Washington Univ. in St. Louis (United States)
K. M. Shihab Uddin, Washington Univ. in St. Louis (United States)
Hongbo Luo, Washington Univ. in St. Louis (United States)
Stephen Rogers, Washington Univ. in Saint Louis (United States)
Allan Doctor, Washington Univ. in Saint Louis (United States)
Quing Zhu, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray