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Proceedings Paper

Polarization sensitive optical coherence tomography for assessing skin roughness
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Paper Abstract

Skin cancer is the most common form of cancer in North America, and melanoma is the most deadly form of skin cancer. Roughness assessment of epidermis has been shown to be valuable in detecting potential skin neoplasia. However, the existing roughness assessment techniques cannot also provide volumetric information. For greater insight, we propose polarization sensitive optical coherence tomography (PS-OCT) for skin assessment. The intensity channel of OCT visualizes the layered structure and surface roughness profile of skin in 3D. Furthermore, PS-OCT can simultaneously conduct polarization related measurements such as the degree of polarization uniformity (DOPU) in a separate imaging channel. Skin phantoms of different surface roughness ranging from 1 to 68 μm have been studied. It was observed that for rougher surfaces, the roughness can be quantified from the surface profile visible in the intensity channel. In smoother surfaces for which the profile is not sensitive, the DOPU decreases with roughness in a quantifiable correlation. The contrast in the DOPU channel is sensitive to polarization and phase fluctuations. Smoother surfaces tend to maintain the polarization state, whereas the height differences in a rougher surface contribute to larger phase shifts between light waves within the coherence volume, leading to greater depolarization. PS-OCT was also applied to in vivo imaging of human skin. The skin at the palm edge shows lower DOPU compared to the skin on the back of the hand, an indication of greater polarization state modification caused by skin roughness. PS-OCT can provide a comprehensive evaluation of skin, which has great potential for detecting melanoma.

Paper Details

Date Published: 19 February 2020
PDF: 7 pages
Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110A (19 February 2020); doi: 10.1117/12.2547139
Show Author Affiliations
Xin Zhou, The Univ. of British Columbia (Canada)
Daniel C. Louie, The Univ. of British Columbia (Canada)
Cancer Control Research Program (Canada)
Sina Maloufi, The Univ. of British Columbia (Canada)
Lin Huang, The Univ. of British Columbia (Canada)
Qihao Liu, The Univ. of British Columbia (Canada)
Lioudmila Tchvialeva, The Univ. of British Columbia (Canada)
Cancer Control Research Program (Canada)
Tim K. Lee, The Univ. of British Columbia (Canada)
Cancer Control Research Program (Canada)
Shuo Tang, The Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 11211:
Photonics in Dermatology and Plastic Surgery 2020
Bernard Choi; Haishan Zeng, Editor(s)

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