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Proceedings Paper

Non-invasive membrane potential measurements using endogenous markers
Author(s): Georgi I. Petrov; Vladislav V. Yakovlev
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Paper Abstract

Measurements and imaging of the electric and magnetic fields inside living cells are important for understanding many biophysical interactions. In particular, membrane potential plays a critical role in cellular communication processes, regulation of active transport and generation of action potential. While most of the active research is focused on developing fluorescent labels for detecting and quantifying membrane potential, the use of endogenous markers for the electric field potential measurements would allow extended measurements of the electric field potential, which could be important both for fundamental research and clinical studies. In this report, the vibrational Stark spectroscopy is evaluated. It is demonstrated that it has sufficient sensitivity to assess physiologically significant variations of the membrane potential.

Paper Details

Date Published: 6 March 2020
PDF: 6 pages
Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 1125606 (6 March 2020); doi: 10.1117/12.2547123
Show Author Affiliations
Georgi I. Petrov, Texas A&M Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 11256:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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