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Proceedings Paper

Perspectives on the phase 0 clinical trial of microdose administration of ABY-029 for fluorescence guided surgery: stability testing
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Paper Abstract

ABY-029, an anti-epidermal growth factor receptor (EGFR) Affibody molecule labeled with IRDye 800CW, has been used in three Phase 0 microdosing clinical trials for fluorescence guided surgery. In May of 2019, the clinical trials were put on hold because the ABY-029 produced under Good Manufacturing Practices (GMP) for human administration had come to the end of term in which the drug product was known to be stable. Stability testing was halted due to limitations in supply of a suitable reference standard and a required test product being discontinued from commercial sale. In order to complete the remaining patients in the three clinical trials, new stability tests were developed and the GMP batch of ABY- 029 drug product tested under the new protocols. The GMP batch of ABY-029 passed all stability tests under the new protocols and the Federal Drug Administration (FDA) has given permission to complete the remaining patients with stability testing of ABY-029 performed for each patient. The tests developed and used to test ABY-029 drug product stability are described here.

Paper Details

Date Published: 19 February 2020
PDF: 8 pages
Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220X (19 February 2020); doi: 10.1117/12.2547110
Show Author Affiliations
Kimberley S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States)
Geisel School of Medicine at Dartmouth (United States)
Sally Hull, Dartmouth College (United States)
Jonathan Elliott, Dartmouth-Hitchcock Medical Ctr. (United States)
Geisel School of Medicine at Dartmouth (United States)
Hira Shahzad Sardar, Dartmouth College (United States)
Jason Gunn, Dartmouth College (United States)
Konstantinos Linos, Geisel School of Medicine at Dartmouth (United States)
Dartmouth-Hitchcock Medical Ctr. (United States)
Laura Tafe, Geisel School of Medicine at Dartmouth (United States)
Dartmouth Hitchcock Medical Ctr. (United States)
Brent Harris, Georgetown Univ. Medical Ctr. (United States)
Joachim Feldwisch, Affibody AB (Sweden)
Brian W. Pogue, Dartmouth College (United States)
David Roberts, Dartmouth-Hitchcock Medical Ctr. (United States)
Eric Henderson, Dartmouth-Hitchcock Medical Ctr. (United States)
Joseph Paydarfar, Dartmouth-Hitchcock Medical Ctr. (United States)
Geisel School of Medicine at Dartmouth (United States)
Keith Paulsen, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)

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