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Proceedings Paper

Integrated optofluidics: label-free isolation of nanoscale bioparticles from heterogenous samples (Conference Presentation)
Author(s): Xiangchao Zhu; Ahmet Cicek; Yixiang Li; Ahmet Ali Yanik

Paper Abstract

We introduce Optofluidic PlasmonIC (OPtIC) microlenses to overcome the shortcomings of existing optical chromatography techniques by eliminating the need for sophisticated instrumentation and pre- cise alignment requirements. Our sub-wavelength thick (~200 nm thick) OPtIC microlenses offer objective-free focusing and self-alignment of optical and fluidic drag forces and present a facile platform for selective separation of exosome size bioparticles. By allowing direct coupling of collimated broadband light to realize strong optical scattering forces at a focal point, extremely small footprint (4 μm × 4 μm) OPtIC microlenses open the door for drastically multiplexed optical chromatography and high-throughput sample processing capability.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 112350T (9 March 2020); doi: 10.1117/12.2547106
Show Author Affiliations
Xiangchao Zhu, Univ. of California, Santa Cruz (United States)
Ahmet Cicek, Burdur Mehmet Akif Ersoy Üniv. (Turkey)
Yixiang Li, Univ. of California, Santa Cruz (United States)
Ahmet Ali Yanik, Univ. of California, Santa Cruz (United States)

Published in SPIE Proceedings Vol. 11235:
Microfluidics, BioMEMS, and Medical Microsystems XVIII
Bonnie L. Gray; Holger Becker, Editor(s)

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