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Proceedings Paper

Estimating drug delivery using hybrid system for simultaneous dynamic MRI and fluorescence tomography
Author(s): Boyu Meng; Margaret R. Folaron; Rendall R. Strawbridge; Kimberley S. Samkoe; Kenneth M. Tichauer; Scott C. Davis
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Paper Abstract

Optical tomography is often coupled with high resolution imaging modality like MRI to provide functional information associated with specific anatomical structure noninvasively. MRI-coupled paired agent fluorescence molecular tomography (MRI-PAFT) is a hybrid imaging modality capable of noninvasively quantifying drug-target engagement in vivo utilizing a targeted and an untargeted fluorescence agent. This study compares the uptake kinetics of MRI contrast agent and fluorescence agents in tumor and normal tissue, and demonstrates the potential of utilizing MRI contrast agent kinetic and targeted fluorescence agent kinetics to quantify targeted tumor receptor concentration in glioma tumor model.

Paper Details

Date Published: 19 February 2020
PDF: 5 pages
Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 1121909 (19 February 2020); doi: 10.1117/12.2547083
Show Author Affiliations
Boyu Meng, Dartmouth College (United States)
Margaret R. Folaron, Dartmouth College (United States)
Rendall R. Strawbridge, Dartmouth College (United States)
Kimberley S. Samkoe, Dartmouth College (United States)
Kenneth M. Tichauer, Illinois Institute of Technology (United States)
Scott C. Davis, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 11219:
Visualizing and Quantifying Drug Distribution in Tissue IV
Kin Foong Chan; Conor L. Evans, Editor(s)

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