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Proceedings Paper

Human glioma tumors detection by a portable visible resonance Raman analyzer with a hand-held optical fiber probe
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Paper Abstract

Based on Visible Resonance Raman (VRR) method, we have developed a novel label-free portable VRR LRR2000 Raman analyzer with a portable fiber-optic probe and used it for the classification of human gliomas ex vivo and for the analysis of changes in tumor chemical compositions in molecular level. The purpose of this study was to examine the performance of the LRR2000 Raman analyzer as an optical biopsy tool for detecting human brain tumors compared to the commercial laboratory HR800 and WITec300 micro confocal Raman spectroscopy instruments. As of 2018, a total 1,938 VRR spectra were collected using LRR2000, HR800 and WITec300 Raman system, ex vivo. Identification of the four grades of glioma tumors and control tissues was performed based on the characteristic native molecular fingerprints. LRR2000 demonstrated consistent diagnostic results with HR800 and WITec300 Raman systems. LRR2000 showed the advantages of high speed, convenience and low cost compared to the two confocal micro Raman systems. Using artificial intelligence (AI)-based analysis of part of the data, the cross-validated accuracy for identifying glioma tumors is ~90% compared with gold standard histopathology examination.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 1123608 (21 February 2020); doi: 10.1117/12.2547070
Show Author Affiliations
Yan Zhou, Air Force Medical Ctr. (China)
Shengjia Zhang, Jiangsu Raman Medical Equipment Co., Ltd. (China)
Binlin Wu, Southern Connecticut State Univ. (United States)
Xinguang Yu, The General Hospital of the Air Force, PLA (China)
Gangge Cheng, Air Force Medical Ctr. (China)
Ke Zhu, Institute of Physics (China)
Mingyue Zhao, Air Force Medical Ctr. (China)
Jichun Zheng , Air Force Medical Ctr. (China)
Liang Zhang, PLA General Hospital (China)
Mingqian Zhang, China Academy of Space Technology (China)
Qijun Liang, China Academy of Space Technology (China)
Yun Ii Go, Heriot-Watt Univ. (Malaysia)
Chunyuan Zhang, City College of New York (United States)
Cheng-hui Liu, City College of New York (United States)
Robert R. Alfano, The City College of New York (United States)

Published in SPIE Proceedings Vol. 11236:
Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry
Wolfgang Petrich; Zhiwei Huang, Editor(s)

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