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Proceedings Paper

Tumor margin assessment using frozen sections can be improved by paired-agent imaging (Conference Presentation)

Paper Abstract

During resection of head and neck cancers, surgeons collect multiple small tissue samples from the excision wound bed for “frozen section” analysis by a clinical pathologist to determine clear margins. However, this process is disruptive to work flow, time-consuming, and expensive. We have validated Paired-Agent Imaging (PAI) in in vivo xenograft models using epidermal growth factor receptor and demonstrated that PAI exhibits higher diagnostic accuracy targeted agent alone – tested in both fresh tissue (~3-mm) and frozen sections (10-m). Here PAI will be extended to screening of tissue biopsies to quantify tumor burden in comparison to standard frozen section pathology.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220N (10 March 2020); doi: 10.1117/12.2547011
Show Author Affiliations
Kimberley S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States)
Cheng Wang, Dartmouth College (United States)
Eunice Chen, Dartmouth-Hitchcock Medical Ctr. (United States)
Laura Tafe, Dartmouth-Hitchcock Medical Ctr. (United States)
Kenneth Tichauer, Illinois Institute of Technology (United States)


Published in SPIE Proceedings Vol. 11222:
Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Sylvain Gioux; Summer L. Gibbs; Brian W. Pogue, Editor(s)

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