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Proceedings Paper

Multifractal OCT for optical detection of retinal function (Conference Presentation)

Paper Abstract

Herein, we report use of near-infrared low-coherent light for non-contact, label-free in-vivo detection of retinal activity in response to visual illumination. Our multifractal phase-OCT employ phase/multifractal analysis to decipher layer specific cellular activity during visual stimulation to assess the functional state of retina. Our OCT-based interferometric technique coupled with in-depth multifractal analysis differentiated retinal activities between wild-type and mice with retinal dystrophy. Our findings open up possibility of clinical translation of multifractal phase-OCT for non-contact label free evaluation of retina health, progression of retinal dystrophies, and as well as for monitoring functional recovery after therapy.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270J (9 March 2020); doi: 10.1117/12.2547004
Show Author Affiliations
Subrata Batabyal, Nanoscope Technologies, LLC (United States)
Sanghoon Kim, Nanoscope Technologies, LLC (United States)
Michael Carlson, Nanoscope Technologies, LLC (United States)
Weldon W. Wright, Nanoscope Technologies, LLC (United States)
Samarendra K. Mohanty, Nanoscope Technologies, LLC (United States)

Published in SPIE Proceedings Vol. 11227:
Optogenetics and Optical Manipulation 2020
Samarendra K. Mohanty; E. Duco Jansen; Anna W. Roe, Editor(s)

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