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Proceedings Paper

Fluorescence dosimetry for indoor-daylight photodynamic therapy: clinical results using wide-field imaging and point-probe measurements (Conference Presentation)
Author(s): Alberto J. Ruiz; Ethan P. M. LaRochelle; Brian Pogue

Paper Abstract

Clinical use of photodynamic therapy (PDT) is widespread for treatment of actinic keratosis (AKs) based upon ALA induced Protoporphyrin IX (PpIX). Dosimetry of the PpIX levels at the point-of-care can help guide critical decisions in PDT, since studies have shown that initial PpIX accumulation and PDT-induced photobleaching serve as strong indicators for patient outcomes in treatment. Here, we present clinical results using a point-probe spectral dosimeter alongside a translational wide-field cellphone fluorescence system to study outcomes of indoor-daylight PDT for treatment of AKs. The outcomes of this study help advance adoption of point-of-care dosimetry for PDT guidance and helps establish threshold treatment parameters for indoor-daylight PDT.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122007 (10 March 2020); doi: 10.1117/12.2546997
Show Author Affiliations
Alberto J. Ruiz, Dartmouth College (United States)
Ethan P. M. LaRochelle, Dartmouth College (United States)
Brian Pogue, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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