Near infrared spectroscopy (NIRS) combined with diffuse correlation spectroscopy (DCS) enable non-invasive, bedside assessment of brain blood flow and metabolism. In numerous disease states (e.g., stroke, traumatic brain injury) these hemodynamic parameters are deranged, and these derangements have diagnostic and/or prognostic value. However, to best utilize NIRS/DCS data to guide patient care, we need a mechanistic understanding of the molecular changes underlying hemodynamic and metabolic dysfunction. Using a mouse model of repetitive mild traumatic brain injury, we present an example of how preclinical studies with NIRS/DCS can aid in the interpretation and utility of clinical NIRS/DCS datasets.

Date Published: 10 March 2020
PDF
Proc. SPIE 11253, Biomedical Applications of Light Scattering X, 1125308 (10 March 2020); doi: 10.1117/12.2546970

Published in SPIE Proceedings Vol. 11253:
Biomedical Applications of Light Scattering X
Adam Wax; Vadim Backman, Editor(s)