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Proceedings Paper

Development of photodynamic diagnosis and therapy for peritoneal dissemination using NIR fiber laser system
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Paper Abstract

Photodynamic diagnosis and therapy (PDD and PDT) involve the use of photochemical reactions induced by light irradiation with a photosensitizer for the detection and treatment of cancer cells and tissues. 5-Aminolevukinic acid (5-ALA) is a clinically used drug for PDT (5-ALA-PDT) in glioblastoma and bladder cancer. However, the conventional 5-ALA-PDT using visible light sours is not effective for the deep portion of organs and tissues. In this study, to overcome the limitation in penetration depth of 5-ALA-PDT, we developed two-photon excited 5-ALA-PDT system with NIR fiber laser for the effective treatment of peritoneal dissemination in gastric cancer.

Paper Details

Date Published: 19 February 2020
PDF: 6 pages
Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200A (19 February 2020); doi: 10.1117/12.2546958
Show Author Affiliations
Y. Shirasaka, Oita Univ. (Japan)
Y. Oshima, Tohoku Univ. (Japan)
Oita Univ. (Japan)
T. Inoue, Oita Univ. (Japan)
Y. Maeda, RIKEN (Japan)
T. Hiratsuka, Oita Univ. (Japan)
T. Akagi, Oita Univ. (Japan)
K. Suzuki, Oita Univ. (Japan)
T. Shibata, Oita Univ. (Japan)
Y. Ueda, Oita Univ. (Japan)
M. Tojigamori, Oita Univ. (Japan)
H. Shiroshita, Oita Univ. (Japan)
T. Etoh, Tohoku Univ. (Japan)
N. Shiraishi, Oita Univ. (Japan)
M. Inomata, Oita Univ. (Japan)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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