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Proceedings Paper

Photo-released drugs: a targeted treatment approach for arthritis
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Paper Abstract

We have developed a technology that facilitates the targeted delivery of glucocorticoids to arthritic joints thereby side-stepping systemic immune suppression while potentially improving efficacy. Our technology loads phototherapeutics inside of red blood cell (RBC) carriers. This ensures that the inactive, RBC-contained phototherapeutic drug is transported throughout the body and released from the RBC carrier only after triggered release by long-wavelength light. We have demonstrated that medications bound to vitamin B12 can be photo-released from RBCs using tissue penetrating, longwavelength red, far-red, and near infrared light in the collagen antibody-induced arthritis model.

Paper Details

Date Published: 19 February 2020
PDF: 8 pages
Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230R (19 February 2020); doi: 10.1117/12.2546949
Show Author Affiliations
Victoria Wickenheisser, Duke Univ. (United States)
Emilia M. Zywot, The Univ. of North Carolina at Chapel Hill (United States)
Emily Rabjohns, Duke Univ. (United States)
Natalia Orlova, The Univ. of North Carolina at Chapel Hill (United States)
Christina M. Marvin, The Univ. of North Carolina at Chapel Hill (United States)
Song Ding, The Univ. of North Carolina at Chapel Hill (United States)
David S. Lawrence, Duke Univ. (United States)
The Univ. of North Carolina at Chapel Hill (United States)
Teresa R. Tarrant, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

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