Share Email Print
cover

Proceedings Paper

Visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime (Conference Presentation)
Author(s): Julien Bec; Deborah Vela; Jennifer E. Phipps; Michael Agung; Jakob Unger; Ken B. Margulies; Maximilian Buja; Laura Marcu

Paper Abstract

Fluorescence Lifetime Imaging (FLIm) is a label-free technique that provides biochemical information from biological samples derived from tissue autofluorescence. Using a custom multispectral FLIm/IVUS catheter system, fluorescence lifetime data (n=33,980 locations) was collected from ex vivo human artery segments (n=32 samples). Our findings indicate that intravascular spectroscopy with FLIm supports the identification of early progression-prone lesions, characterized by the accumulation of extracellular lipids, as well as the quantification of inflammatory activity, characterized by macrophage foam cells accumulation. This information improves our understanding of plaque development, which may ultimately be used to improve risk assessment of acute coronary events.

Paper Details

Date Published: 9 March 2020
PDF
Proc. SPIE 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020, 112150E (9 March 2020); doi: 10.1117/12.2546921
Show Author Affiliations
Julien Bec, Univ. of California, Davis (United States)
Deborah Vela, The Texas Heart Institute (United States)
Jennifer E. Phipps, Univ. of California, Davis (United States)
Michael Agung, Univ. of California, Davis (United States)
Jakob Unger, Univ. of California, Davis (United States)
Ken B. Margulies, Perelman School of Medicine, Univ. of Pennsylvania (United States)
Maximilian Buja, The Texas Heart Institute (United States)
Laura Marcu, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 11215:
Diagnostic and Therapeutic Applications of Light in Cardiology 2020
Kenton W. Gregory M.D.; Laura Marcu, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray