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Proceedings Paper

Investigation of adsorption and release of photodynamic dyes by Clinoptilolite zeolite
Author(s): Anupama Nair; V. A. Hovhannisyan; Shean-Jen Chen
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Paper Abstract

This study investigated the use of clinoptilolite zeolites (CZs) as the drug adsorbent and their ability to release 5- Aminolevulinic acid (5-ALA) and porphyrin (Zn-TBut3 PyP) in the presence of biomolecules, by absorption and fluorescence spectrometry and multiphoton spectroscopy. About one-third of the porphyrin adsorbed on to CZs was released in the presence of biomolecule such as insulin. In-vitro measurements show that the skin absorbed the dye more than 1.5 times for ALA-CZ and porphyrin-CZ complex compared to non-CZ form. The measurements on chicken skin were also performed using multiphoton microscopy which compared the penetration of the dye into the skin in the presence and absence of CZ. These results demonstrate the potential of CZ in the efficient adsorption and biomolecule favoured release of 5-ALA and porphyrin in biological systems.

Paper Details

Date Published: 16 March 2020
PDF: 5 pages
Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200G (16 March 2020); doi: 10.1117/12.2546905
Show Author Affiliations
Anupama Nair, National Chiao Tung Univ. (Taiwan)
V. A. Hovhannisyan, National Chiao Tung Univ. (Taiwan)
Shean-Jen Chen, National Chiao Tung Univ. (Taiwan)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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