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Proceedings Paper

Wide-field dual-probe imaging approach validated using QDs and skin mimicking phantoms (Conference Presentation)

Paper Abstract

We utilized these NIR QDs to demonstrate the utility of an image processing algorithm capable of determining the relative concentration ratios of two distinct emitters at various tissue depths. This algorithm is based on the dual probe imaging method, which we modified for use in wide-field imaging systems. The algorithm was validated using skin-mimicking tissue phantoms that were used to vary the effective imaging depth from 0-1.2 mm. The algorithm correctly determined concentration ratios of a two-color QD system for variations in concentration ≥ 10%, independently of depth. These contrast agents and the imaging approach are being adapted for use for in vivo targeted tumor imaging.ng adapted for use for in vivo targeted tumor imaging.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540F (10 March 2020); doi: 10.1117/12.2546864
Show Author Affiliations
Alexander Saeboe, Boston Univ. (United States)
Keyi Han, Boston Univ. (United States)
Joshua Kays, Boston Univ. (United States)
Reyhaneh Toufanian, Boston Univ. (United States)
Allison Dennis, Boston Univ. (United States)


Published in SPIE Proceedings Vol. 11254:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII
Dror Fixler; Ewa M. Goldys, Editor(s)

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