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Proceedings Paper

Eradication of broad-spectrum multi-drug fungal pathogens through photoinactivation of a detoxifying enzyme (Conference Presentation)

Paper Abstract

Candida auris, the deadly infectious fungus, was reported to infest nearly 60 hospitals and more than 90 nursing homes in New York City. Moreover, these fungal species have developed resistance to all three major anti-fungal drugs. Drug-resistant Candida spp. and other non-albicans have developed multi-drug resistance around the world. Here, we show that, through efficient photoinactivation of an essential detoxifying enzyme which exists in most of the fungal strains, we could achieve significant eradication of those pathogens by subsequent administration of low-concentration of hydrogen peroxide and antifungal drugs. Noteworthy, hydrogen peroxide or antifungal alone is not effective to eradicate them.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230U (10 March 2020); doi: 10.1117/12.2546838
Show Author Affiliations
Pu-Ting Dong, Boston Univ. (United States)
Zeina Dagher, Massachusetts General Hospital (United States)
Yuewei Zhan, Boston Univ. (United States)
Jie Hui, Boston Univ. (United States)
Michael K. Mansour, Massachusetts General Hospital (United States)
Ji-Xin Cheng, Boston Univ. (United States)


Published in SPIE Proceedings Vol. 11223:
Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020
Tianhong Dai; Jürgen Popp; Mei X. Wu M.D., Editor(s)

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