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Proceedings Paper

Functional brain mapping in preschool-age children with high density diffuse optical tomography (Conference Presentation)
Author(s): Kalyan Tripathy; Alexa M. Svoboda; Mariel L. Schroeder; Andrew K. Fishell; Edward J. Richter; Sean Rafferty; Christopher Tracy; Zachary E. Markow; Muriah D. Wheelock; Adam T. Eggebrecht; Joseph P. Culver

Paper Abstract

High density diffuse optical tomography (HD-DOT) combines logistical advantages of fNIRS with enhanced image quality, validated extensively against fMRI in adults and neonates. However, HD-DOT is yet to be evaluated in preschool-age children. Here we present an HD-DOT system optimized for preschoolers, including a 128-source by 125-detector console, light-weight fiber optics, and an expanded field-of-view. We validated the system by mapping cortical activations during visual, auditory, and motor tasks in adults. We then imaged children while they watched movies, finding reproducible patterns of brain activity and showing that feature regressors can map functionally specific regions from movie-viewing data in preschoolers.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260E (9 March 2020); doi: 10.1117/12.2546817
Show Author Affiliations
Kalyan Tripathy, Washington Univ. School of Medicine in St. Louis (United States)
Alexa M. Svoboda, Washington Univ. School of Medicine in St. Louis (United States)
Mariel L. Schroeder, Washington Univ. School of Medicine in St. Louis (United States)
Andrew K. Fishell, Washington Univ. School of Medicine in St. Louis (United States)
Edward J. Richter, Washington Univ. School of Medicine in St. Louis (United States)
Sean Rafferty, Washington Univ. School of Medicine in St. Louis (United States)
Christopher Tracy, Washington Univ. School of Medicine in St. Louis (United States)
Zachary E. Markow, Washington Univ. School of Medicine in St. Louis (United States)
Muriah D. Wheelock, Washington Univ. School of Medicine in St. Louis (United States)
Adam T. Eggebrecht, Washington Univ. School of Medicine in St. Louis (United States)
Joseph P. Culver, Washington Univ. School of Medicine in St. Louis (United States)


Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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