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Proceedings Paper

Anticoagulation and hemostasis monitoring at the bedside during cardiac surgical procedures (Conference Presentation)
Author(s): Diane M. Tshikudi; Michael N. Andrawes; Seemantini K. Nadkarni

Paper Abstract

Standard coagulation testing is limited to measuring clotting time and lacks information on global hemostasis and coagulation status of patients undergoing complex cardiac surgical procedures. Here, we assessed the accuracy of our novel bedside optical sensor, iCoagLab, to measure global coagulation status from temporal speckle intensity fluctuations in 25µL of blood obtained from patients during cardiac surgery. Our results showed a dose-dependent prolongation and significant modulation of iCoagLab-ACT, angle and MA metrics throughout surgery which closely mirrored standard-reference Hepcon-ACT measurements. In conclusion, iCoagLab accurately assessed global hemostasis using a drop of blood, likely opening the opportunity for multifunctional, bedside coagulation monitoring in patients undergoing cardiac surgical procedures.

Paper Details

Date Published: 11 March 2020
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Proc. SPIE 11247, Optical Diagnostics and Sensing XX: Toward Point-of-Care Diagnostics, 112470D (11 March 2020); doi: 10.1117/12.2546717
Show Author Affiliations
Diane M. Tshikudi, Massachusetts General Hospital (United States)
Michael N. Andrawes, Massachusetts General Hospital (United States)
Seemantini K. Nadkarni, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11247:
Optical Diagnostics and Sensing XX: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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