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Proceedings Paper

Estimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography
Author(s): Boyu Meng; Rendall R. Strawbridge; Kenneth Tichauer; Kimberley S. Samkoe; Scott C. Davis
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Paper Abstract

Angiogenesis inhibiting cancer therapy has become a standard treatment for many cancer types. The ability to examine the effects of these drugs in tumors noninvasively could help assess efficacy early in the treatment course or identify optimal times to introduce other combinatorial treatments. Herein, we examine whether a paired agent MRI-coupled fluorescence tomography approach can be used to monitor the effects of anti-angiogenesis therapy. Using small animal models bearing orthotopic glioma xenografts, we demonstrate noninvasive quantification of paired-agent uptake in response to anti-angiogenesis therapy in vivo. The result provides insights on receptor targeted drug delivery in altered vasculature, a potential important development for treatment monitoring and combinatorial strategies.

Paper Details

Date Published: 2 March 2020
PDF: 5 pages
Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 112160U (2 March 2020); doi: 10.1117/12.2546702
Show Author Affiliations
Boyu Meng, Dartmouth College (United States)
Rendall R. Strawbridge, Dartmouth College (United States)
Kenneth Tichauer, Illinois Institute of Technology (United States)
Kimberley S. Samkoe, Dartmouth College (United States)
Scott C. Davis, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 11216:
Multiscale Imaging and Spectroscopy
Paul J. Campagnola; Kristen C. Maitland; Darren M. Roblyer, Editor(s)

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