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Proceedings Paper

Model impact in resolving DCS CBF measurements from systemic variations in blood flow (Conference Presentation)

Paper Abstract

Diffuse correlation spectroscopy (DCS) is an increasingly widespread non-invasive technology to measure tissue perfusion. Extending this technique into adult brain monitoring to assess real-time cerebral blood flow (CBF) requires addressing the influence of extracerebral contributions on DCS measurements. We compare several Monte Carlo based forward simulation models on the efficacy of CBF isolation, including ones generated directly from individual subject MRI scans. We conclude that a multi-layer curved surface representation is beneficial, and that the traditional single-layer homogenous model is insufficient; however, detailed structural information such as cortical folding represented in an individualized tissue-specific model may not be needed.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260X (9 March 2020); doi: 10.1117/12.2546699
Show Author Affiliations
Melissa M. Wu, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Davide Tamborini, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Kimberly A. Stephens, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Dibbyan Mazumder, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Parya Farzam, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Suk-Tak Chan, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Jason Z. Qu, Massachusetts General Hospital (United States)
Maria A. Franceschini, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Stefan A. Carp, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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