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Proceedings Paper

Fiber optic biosensor based on polydimethylsiloxane (PDMS) and bioactive lipids
Author(s): Mildred S. Cano-Velázquez; Luz M. López-Marín; Juan Hernández-Cordero
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Paper Abstract

In this work, we demonstrate an optical fiber biosensor based on Fabry-Perot (F-P) interferometers using polydimethylsiloxane (PDMS) as a support for bioactive lipids. The sensors are fabricated by dip-coating producing PDMS end-capped devices. For biosensing, the PDMS cap was functionalized with a previously characterized bioactive lipid antigen cocktail from Mycobacterium fortuitum, used as a surrogate source of antigens for tuberculosis diagnosis. The performance of the biosensor was evaluated upon monitoring the changes in the interference pattern associated to the interactions between the active lipids and the antibody-containing sera. Our results show that the proposed biosensor offers new and attractive possibilities for developing novel lipidomic analytical tools.

Paper Details

Date Published: 20 February 2020
PDF: 6 pages
Proc. SPIE 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX, 112330Y (20 February 2020); doi: 10.1117/12.2546685
Show Author Affiliations
Mildred S. Cano-Velázquez, Univ. Nacional Autónoma de México (Mexico)
Luz M. López-Marín, Univ. Nacional Autónoma de México (Mexico)
Juan Hernández-Cordero, Univ. Nacional Autónoma de México (Mexico)

Published in SPIE Proceedings Vol. 11233:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX
Israel Gannot, Editor(s)

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