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Proceedings Paper

Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)

Paper Abstract

We demonstrate a contact-lens (CL) based mobile sensing system which can be used to measure protein levels in human tear. By using a cost-effective mobile-phone-based well-plate reader and a fluorescent assay, we quantify lysozyme nonspecifically bound to CLs. We monitored the lysozyme levels of 9 healthy volunteers to establish individual baselines, and then compared these measurements to participants who had been diagnosed with Dry Eye Disease (N=6), observing a statistically significant difference in their means. Due to its non-invasive and simple operation, this method could be used for tear-based sensing and health monitoring applications in point-of-care settings and at home.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11230, Optics and Biophotonics in Low-Resource Settings VI, 112300R (9 March 2020); doi: 10.1117/12.2546656
Show Author Affiliations
Zachary S. Ballard, Univ. of California, Los Angeles (United States)
Sarah Bazargan, Univ. of California, Los Angeles (United States)
Diane Jung, Univ. of California, Los Angeles (United States)
Shyama Sathianathan, Univ. of California, Los Angeles (United States)
Ashley Clemens, Univ. of California, Los Angeles (United States)
Daniel Shir, Univ. of California, Los Angeles (United States)
Saba Al-Hashimi, UCLA Stein Eye Institute (United States)
Aydogan Ozcan, Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 11230:
Optics and Biophotonics in Low-Resource Settings VI
David Levitz; Aydogan Ozcan, Editor(s)

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