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Proceedings Paper

Overlapping volumes, acousto-optic modulated diffuse correlation spectroscopy for increased depth sensitivity (Conference Presentation)

Paper Abstract

Diffuse correlation spectroscopy (DCS) is an established diffuse optical technique that uses the analysis of temporal speckle intensity fluctuations to measure blood flow in tissue. As a non-invasive technique, DCS has been used to monitor patient cerebral blood flow at the bedside. Though an effective measurement tool, extra-cerebral contamination of the DCS signal limits the sensitivity to changes in brain blood flow. In order to overcome this depth sensitivity challenge, we present a method, overlapping volumes, acousto-optic modulated DCS (AOM-DCS), to improve sensitivity to deeper tissue structures.

Paper Details

Date Published: 20 April 2020
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Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402T (20 April 2020); doi: 10.1117/12.2546630
Show Author Affiliations
Mitchell B. Robinson, Harvard-MIT Health Sciences and Technology (United States)
Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Stefan A. Carp, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Sava Sakadzic, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Adriano Peruch, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Davide Tamborini, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Maria Angela Franceschini, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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