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Proceedings Paper

Creation of a non-contact, automated brain tumor detection device for use in brain tumor resection
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Paper Abstract

The ability to differentiate healthy and tumorous tissue is vital during the surgical removal of tumors. This ability is especially critical during neurosurgical tumor resection due to the risk associated with removing healthy brain tissue. In this paper, we present an epifluorescence spectroscopy guided device that is not only capable of autonomously classifying a region of tissue as tumorous or healthy in real-time–but is also able to differentiate between different tumor types. For this study, glioblastoma and melanoma were chosen as the two different tumor types. Six mice were utilized in each of the three classes (healthy, glioblastoma, melanoma) for a total of eighteen mice. A “one-vs-the-all” approach was used to create a multi-class classifier. The multi-class classifier was capable of classifying with 100% accuracy. Future work includes increasing the number of mice in each of the three tumor classes to create a more robust classifier and expanding the number of tumor types beyond glioblastoma and melanoma.

Paper Details

Date Published: 17 February 2020
PDF: 6 pages
Proc. SPIE 11225, Clinical and Translational Neurophotonics 2020, 112250C (17 February 2020); doi: 10.1117/12.2546603
Show Author Affiliations
Matthew B. Tucker, Duke Univ. (United States)
Suzanna Joseph, Duke Univ. (United States)
Weston Ross, Duke Univ. (United States)
Guangshen Ma, Duke Univ. (United States)
Pakawat Chongsathidkiet, Duke Univ. (United States)
Peter Fecci, Duke Univ. (United States)
Patrick Codd, Duke Univ. (United States)
Duke Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 11225:
Clinical and Translational Neurophotonics 2020
Steen J. Madsen; Victor X. D. Yang; Nitish V. Thakor, Editor(s)

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