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Proceedings Paper

Heterogeneity of mitochondria morphology in breast cancer cells
Author(s): Ling Wang; Jamie Ward; Megan Bouyea; Margarida Barroso
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Paper Abstract

Cancer cell growth has been shown to affect receptor expression and organelle morphology. Therefore, differences in mitochondrial morphology and function in cancer cells are of key importance for the successful implementation of targeted drug therapy in the clinic. To improve our understanding of the heterogeneity of mitochondrial morphology in breast cancer cells, we have analyzed the morphology of mitochondria in a comparative manner across 2D-culture breast cancer cell systems. Moreover, we used machine learning methods to develop a classification method that can assign each 3D rendered mitochondrial object to their respective breast cancer cell type with good accuracy.

Paper Details

Date Published: 2 March 2020
PDF: 7 pages
Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 112160P (2 March 2020); doi: 10.1117/12.2546594
Show Author Affiliations
Ling Wang, Albany Medical College (United States)
Jamie Ward, Albany Medical College (United States)
Megan Bouyea, Albany Medical College (United States)
Margarida Barroso, Albany Medical College (United States)

Published in SPIE Proceedings Vol. 11216:
Multiscale Imaging and Spectroscopy
Paul J. Campagnola; Kristen C. Maitland; Darren M. Roblyer, Editor(s)

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