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Proceedings Paper

Photoacoustic monitoring of drug release from PLGA nanocarriers for tumor treatment (Conference Presentation)
Author(s): Jeanne Lemaster

Paper Abstract

This study details the synthesis and time release properties of a paclitaxel-methylene blue drug incapsulated in a PLGA nanoparticle. The most important finding is that a redox switch of the methylene blue between the leuco and oxidized forms causes a change from photoacoustically silent to photoacoustically active states which was used to monitor drug release in vivo. We used this photoacoustic signal change to monitor drug release from paclitaxel-methylene blue encapsulated in PLGA in a murine model.

Paper Details

Date Published: 10 March 2020
PDF
Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540A (10 March 2020); doi: 10.1117/12.2546572
Show Author Affiliations
Jeanne Lemaster, Univ. of California, San Diego (United States)


Published in SPIE Proceedings Vol. 11254:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII
Dror Fixler; Ewa M. Goldys, Editor(s)

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