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Proceedings Paper

Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)
Author(s): Danielle Ornelas; Md. Hasan; Jenny Szu; Oscar Gonzalez; Timothy Myers; Koji Hirota; Melissa Eberle; Maksim Bazhenov; Devin Binder; B. Hyle Park

Paper Abstract

Optical coherence tomography (OCT) is a label-free, high resolution, and minimally invasive imaging technique that can produce depth-resolved cross-sectional and 3D images. We sought to examine non-vascular depth-dependent optical changes directly related to neural activity in the brain using OCT. Results of this study show a significant temporal correlation between non-vascular decrease in attenuation in ex vivo and in vivo seizure models and increased electrical activity during seizure. This study allows for a more thorough and biologically relevant analysis of the optical signature of seizure activity ex vivo and in vivo using OCT.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280O (9 March 2020); doi: 10.1117/12.2546560
Show Author Affiliations
Danielle Ornelas, Univ. of California, Riverside (United States)
Md. Hasan, Univ. of California, Riverside (United States)
Jenny Szu, Univ. of California, Riverside (United States)
Oscar Gonzalez, Univ. of California, San Diego (United States)
Timothy Myers, Univ. of California, Riverside (United States)
Koji Hirota, Univ. of California, Riverside (United States)
Melissa Eberle, Univ. of California, Riverside (United States)
Maksim Bazhenov, Univ. of California, San Diego (United States)
Devin Binder, Univ. of California, Riverside (United States)
B. Hyle Park, Univ. of California, Riverside (United States)


Published in SPIE Proceedings Vol. 11228:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV
Joseph A. Izatt; James G. Fujimoto, Editor(s)

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